Commentary on: Budowle B, Shea B, Niezgoda S, Chakraborty r. CODIS STR loci data from 41 sample populations. J Forensic Sci 2001;46:453-489

TitleCommentary on: Budowle B, Shea B, Niezgoda S, Chakraborty r. CODIS STR loci data from 41 sample populations. J Forensic Sci 2001;46:453-489
Publication TypeJournal Article
Year of Publication2004
AuthorsDan Krane, Travis Doom, L. Mueller, Michael Raymer, W. Shields, William Thompson
JournalJournal of Forensic Science
Volume49
Issue6
Pagination1388-1389
Date Published11/2004
PublisherASTM International
KeywordsAfrican American, Asian, Caucasian, forensic science, FST, Hardy-Weinberg Expectations, Hispanic, Native American, PCR, population databases, STR
Abstract

In an article on allele frequencies for CODIS loci in 41 different populations, Budowle et al. (1) reported no significant deviations from Hardy-Weinberg expectations (HWE) after making the Bonferroni correction for multiple tests. However, examination of the data reported in (1) for two Native American populations, Navaho and Salishan, shows significant departures from HWE at three loci for each population. Budowle et al. appear to have relied on an incorrect and unsupportable application of the Bonferroni correction (2,3) to disregard these deviations. These loci should not be used when the product rule is employed to compute the frequency of multi-locus genotypes in these populations unless appropriate corrective actions are taken to account for the observed deviations from HWE.

DOI10.1520/JFS2004162
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  • Krane, D., Doom, T., Mueller, L., Raymer, M., Shields, W., & Thompson, W. (2004). "Commentary on: Budowle B, Shea B, Niezgoda S, Chakraborty R. CODIS STR loci data from 41 sample populations. L Forensic Sci 2001; 46:453–489." Journal of Forensic Sciences, 49 (6), JFS2004162-2. https://doi.org/10.1520/JFS2004162